Cholesterolosis of Gallbladder: A Case Report : Cholesterolosis of Gallbladder

Dr. Harsha  Jaykar; Dr. Gauri  Metkar; Mangala Nagare; Dr. Sarangi Wankhade; Dr. Suraj  Sangale; Dr. Rajendra  Zope; Dr. Janice  Jaison; Dr. Simta  Bhide

Authors

Dr. Harsha Jaykar Associate Professor
Dr. Gauri Metkar Professor
Mangala Nagare Associate Professor
Dr. Sarangi Wankhade Post Graduate 3rd year MD student
Dr. Suraj Sangale Post Graduate 3rd year MD student
Dr. Rajendra Zope Associate Professor
Dr. Janice Jaison Professor
Dr. Simta Bhide Professor,HOD Department Pathology

Keywords:

Cholesterolosis, Cholesterol, Gallbladder

Abstract

Abstract- Cholesterolosis, a rare surgical disorder, is characterized by the abnormal and excessive accumulation of triglycerides and cholesterol esters in the gallbladder's macrophages. This condition is more prevalent in females around the sixth decade of life and is relatively uncommon in younger individuals. Here, we present a case of a young female who experienced right hypochondrial pain along with abdominal discomfort. Clinically diagnosed with cholecystitis, she underwent a cholecystectomy, and incidentally, histomorphological examination revealed cholesterolosis.

References

Almas T, Murad MF, Khan MK, Ullah M, Nadeem F, Ehtesham M, Zaidi SMJ. The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study. Cureus. 2020 Aug 9;12(8):e9627. doi: 10.7759/cureus.9627. PMID: 32923228; PMCID: PMC7478930.

Cholesterosis of the gallbladder: an autopsy study of 165 cases. Feldman M, Feldman M, Jr Jr. Gastroenterology. 1954;27:641–648. [PubMed] [Google Scholar] [Ref list]

Cholesterosis of the gallbladder. Surgical considerations. Salmenkivi K. https://pubmed.ncbi.nlm.nih.gov/5906877/ Int Surg. 1966;45:304–309. [PubMed] [Google Scholar] [Ref list]

Zakko WF, Zakko SF. Gallbladder polyps and cholesterolosis. Monografía en Internet] UpToDate.[Consultado en Diciembre 2014]. Disponible en. 2013.

New 5.Abukhiran I, Jasser J, Farhat I, Boukhar S. Case of a large pedunculated biliary cholesterol polyp with osseous metaplasia. Cureus. 2020 Dec 29;12(12).

Bendjaballah A, Taieb M, Khiali R, Djouini MI, Mechri S, Ammari S. Cholesterolosis of Gallbladder; an Unusual Cause of Acute Recurrent Pancreatitis. World J Surg Surgical Res. 2020; 3.;1210.

Soundrapandian F, Durairaj B, Kashyap AR, Jose R. Strawberry gallbladder: a case report. Journal of Evolution of Medical and Dental Sciences. 2016 Mar 24;5(24):1313-5.

Cocco G, Basilico R, Delli Pizzi A, Cocco N, Boccatonda A, D'Ardes D, Fabiani S, Anzoletti N, D'Alessandro P, Vallone G, Cipollone F, Schiavone C. Gallbladder polyps ultrasound: what the sonographer needs to know. J Ultrasound. 2021 Jun;24(2):131-142. doi: 10.1007/s40477-021-00563-1. Epub 2021 Feb 6. PMID: 33548050; PMCID: PMC8137797.

Yaylak F, Deger A, Ucar BI, Sonmez Y, Bayhan Z, Yetisir F. Cholesterolosis in routine histopathological examination after cholecystectomy: what should a surgeon behold in the reports?. International Journal of Surgery. 2014 Nov 1;12(11):1187-91.

Jacyna MR, Ross PE, Bakar MA, Hopwood D, Bouchier IA. Characteristics of cholesterol absorption by human gall bladder: relevance to cholesterolosis. J Clin Pathol. 1987 May;40(5):524-9. doi: 10.1136/jcp.40.5.524. PMID: 3584503; PMCID: PMC1141017.

Watanabe F, Hanai H, Kaneko E. Increased acylCoA-cholesterol ester acyltransferase activity in gallbladder mucosa in patients with gallbladder cholesterolosis. Am J Gastroenterol. 1998 Sep;93(9):1518-23. doi: 10.1111/j.1572-0241.1998.00473.x. PMID: 9732935.

Bendjaballah A, Taieb M, Khiali R, Djouini MI, Mechri S, Ammari S. Cholesterolosis of Gallbladder; an Unusual Cause of Acute Recurrent Pancreatitis. World J Surg Surgical Res. 2020; 3.;1210.

Sandri L, Colecchia A, Larocca A, et al. Gallbladder cholesterol polyps and cholesterolosis. Minerva Gastroenterologica e Dietologica. 2003 Sep;49(3):217-224. PMID: 16484961.

Vagholkar K, Chandrashekhar S, Singh S, Narang N, Bhadavankar A. Cholesterolosis of the gall bladder: a surgical dilemma. International Surgery Journal. 2021;8(1):375-7.

Owen CC, Bilhartz LE. Gallbladder polyps, cholesterolosis, adenomyomatosis, and acute acalculous cholecystitis. Semin Gastrointest Dis. 2003 Oct;14(4):178-88. PMID: 14719768.

Cholesterolosis of Gallbladder: A Case Report